With MySQL 5.5 the default storage engine was changed to InnoDB. This was a good step as most users expected MySQL to support transactions, row level locking and all the other InnoDB features, but with 5.1 they sometimes forgot to choose the right storage engine. As most databases don't have multiple storage engines and many MySQL users changed the default storage engine to InnoDB this made the switch to MySQL easier and the default behaviour more in line with what people expect from a relational database. Changing the storage engine can of course be done on a per table or per instance basis (default-storage-engine in my.cnf). The temporary tables created with 'CREATE TEMPORARY TABLE ...' should not be forgotten. The performance of InnoDB or MyISAM for temporary tables can have quite some impact, especially with slow storage, a buffer pool which is too small to hold the complete dataset or very small temporary tables. In MySQL 5.6 there is a new variable introduced to se...

For MyISAM one of the most important variables is the Key Buffer.  The Key Buffer is sometimes called the Key Cache. It's used as a buffer for the indices of MyISAM tables. There is some overhead in the buffer depending on the configured key block size. The official way to calculate the key buffer usage as documented in the MySQL Reference manual: 1 - ((Key_blocks_unused * key_cache_block_size) / key_buffer_size)  This will return the factor, so you have to multiply it with 100 to get the percentage. The Key_blocks_unused is used instead of the more obvious Key_blocks_used. This is due to the fact that Key_blocks_used is the maximum number of key blocks ever used. It will not return to 0 after a FLUSH TABLES. This calculation does not take the overhead in account. The key buffer efficiency can be calculated if the key buffer is empty or (has been) completely full. If the the key buffer is full: key_buffer_coefficient = key_cache_block_size/(key_buffer_size/Key_block...